Radiological Features of B3 Lesions in Mutation Carrier Patients: A Single-Center Retrospective Analysis

Background. To evaluate the radiological features of B3 lesions in patients with genetic mutations to establish an anatomo-radiological correlation. Methods. A total 227 women a histological diagnosis breast lesion were enrolled. Breast images 21 test positivity for genes associated cancer analyzed. Results. BRCA1 was most frequent mutation (n = 12) followed by ATM 6) and BRCA2 3). The findings showed nine atypical ductal hyperplasia (ADH), six lobular neoplasia (LN) including carcinoma situ (LCIS), three flat epithelial atypia (FEA) radial scar (RS) lesions. results significance difference between distribution subgroups mutations. LN FEA highest malignancy Patient age risk anamnesis factors that significantly influenced rate. By mammography, 90.5% appeared as microcalcifications. ultrasound, 13 observed hypoechoic On MRI, 16 detected mass enhancement all groups. DWI kinetic curves correlated cancer. Conclusions. may help malignancy. high rate our sample suggests they should always be surgically excised.